薛松果

学术职务：上海市医学会生殖医学分会青年委员擅长：临床胚胎学（1）对受精失败、低受精率有丰富处理经验；（2）对反复胚胎差有丰富处理经验；（3）对卵子成熟障碍有丰富处理经验；（4）2007年开始推广胚胎玻璃化冷冻，2008-2010连续三年举办胚胎玻璃化冷冻培训班；（5）原创Cryopiece单精子冷冻（中国第一例单精子冷冻试管婴儿，2016），2017-2020连续四年举办单精子冷冻培训班。发表文章：第一或通讯作者（含共同第一或共同通讯）1.XuY,WangR,PangZ,WeiZ,SunL,LiS,WangG,LiuY,ZhouY,YeH,JinL,XueS.NovelHomozygous PADI6 VariantsinInfertileFemaleswithEarlyEmbryonicArrest[J].FrontCellDevBiol.2022Apr1;10:819667.doi:10.3389/fcell.2022.819667.eCollection2022.2.YuK,WangRX,LiMH,SunTC,ZhouYW,LiYY,SunLH,ZhangBL,LianZX,XueSG,LiuYX,DengSL.Melatonin Reduces Androgen ProductionandUpregulatesHemeOxygenase-1ExpressioninGranulosaCellsfromPCOSPatientswithHypoestrogeniaandHyperandrogenia[J].OxidMedCellLongev.2019Oct20;2019:8218650.doi:10.1155/2019/8218650.eCollection2019.PMID:31772710 3.SunL,TianH,XueS,YeH,XueX,WangR,LiuY,ZhangC,ChenQ,GaoS.Tie1contributestothedevelopmentofovarianhyperstimulationsyndromeundertheregulationofEGR1ingranulosacells[J].ExpMolMed.2022Jan;54(1):81-90.doi:10.1038/s12276-021-00722-8.Epub2022Jan25.PMID:350791184.Zhao,L#,Xue,S#,Yao,Z#.etal.BiallelicmutationsinCDC20causefemaleinfertilitycharacterizedbyabnormalitiesinoocytematurationandearlyembryonicdevelopment.ProteinCell(2020).https://doi.org/10.1007/s13238-020-00756-05.中国男性生育力保存专家共识编写组（专家）.中国男性生育力保存专家共识[J]. 中华生殖与避孕,2021,41(3):191-198DOI:10.3760/cma.j.cn101441-20200831-00469.6.王荣祥,喻乔,彭秋平,曹少锋,张彩霞,刘宇,周怡雯,薛松果.自制冷冻片微型载体（Strawtop）微量精液冻存效果的实验研究[J].中华生殖与避孕杂志,2020,40(12):1006-1012.DOI:10.3760/cma.j.cn101441-20191014-00458.7.YaoXu,YingQian,YuLiu,QiaofengWang,RongxiangWang,YiwenZhou,CaixiaZhang,ZhiPang,HongjuanYe,SongguoXue*,LihuaSun*.AnovelhomozygousvariantinNLRP5isassociatewithhumanearlyembryonicarrestinaconsanguineousChinesefamily.ClinGenet.2020Mar29.doi:10.1111/cge.13744.Onlineaheadofprint.8.Yu,Kun,Wang,Rong-Xiang,Li,Meng-Hui,Sun,Tie-Cheng,Zhou,Yi-Wen,Li,Yuan-Yuan,Sun,Li-Hua,Zhang,Bao-Lu,Lian,Zheng-Xing*,Xue,Song-Guo*,Liu,Yi-Xun,Deng,Shou-Long*.MelatoninReducesAndrogenProductionandUpregulatesHemeOxygenase-1ExpressioninGranulosaCellsfromPCOSPatients,withHypoestrogeniaandHyperandrogenia.OxidativeMedicineandCellularLongevity,2019Oct20;2019:8218650.doi:10.1155/2019/8218650.eCollection2019.9.YaoWang,Mei-linZhang,Lei-wenZhao,Yan-pingKuang,Song-guoXue*.Enhancementoftheefficiencyofoocytevitrificationthroughregulationofhistonedeacetylase6expression.JAssistReprodGenet.2018Jul;35(7):1179-1185.10.WeiranChai,RongxiangWang,XiaoweiWen,HaiyanGuo,HuiLong,ZhengYan,QifengLyu,YanpingKuang,SongguoXue*.Transferofvitrified-warmedday7blastocystsfollowinginvitrofertilization/intracytoplasmicsperminjectiontoChinesewomenresultedinthesuccessfuldeliveryofnineteenhealthybabies.AmJClinExpObstetGynecol2016;3(2):32-39.11.SongguoXue,QiupingPeng,QiaoYu,QifengLyu,ShaofengCao,YanpingKuang*,Sucrosepretreatmentvitrificationyields100%survivalrateofmouseandhumaneggs,The2ndWorldCongressonFertilityPreservation,USA,2011.12.08-10,Journalofassistedreproductionandgenetics,28,1002-1003.12.SongguoXue,QiupingPeng,ShaofengCao,QiaoYu,JiqiangSi,YanpingKuang*,Cryopreservationofasmallnumberofhumanspermatozoawithhome-madeStrawtop:3yearsexperience.The2ndWorldCongressonFertilityPreservation,USA,2011.12.08-10,Journalofassistedreproductionandgenetics,28,991-992.13.Qiu-PingPeng,Shao-FengCao,Qi-FengLyu,Song-GuoXue*,WeiJin,Xiao-YinLiu,Wen-JieZhang,H.IngolfNielsen,Yan-PingKuang.Anovelmethodforcryopreservationofindividualhumanspermatozoa.InVitroCellular&DevelopmentalBiology-Animal.2011,47(8):565-72.14.S.Xue,Q.Lyu,Q.Peng,S.Cao,Y.Zhou,Y.Kuang*,Vitrificationyieldssuperiorefficiencyofhumancleavage-stageembryocryopreservationversusslow-freezing,The66thASRMAnnualMeeting,USA,2010.10.23-27,P90,posterpresentation.15.X.Liu,S.Xue,W.Jin,etal.ImpactofIncubationTimeofVitrification-warmingEmbryoonFrozen-thawedEmbryoTransfer.JournalofReproductiveMedicine,2010,19:104-107.16.SXue,J.Yang,F.Yao,etal.Recurrentspontaneousabortionspatientshavemore−14bp/+14bpheterozygotesinthe3′UTregionoftheHLA-GgeneinaChineseHanpopulation.Tissueantigen.2007,69Suppl1:153-155.17.S.Xue,J.Yang,F.Yao,etal.Studyonthepolymorphismofthe14bpdeletionofHLA-Galleleinpatientswithrecurrentspontaneousabortionofunknownoriginandnormaldeliveries.CurrentImmunology.2006,26(4):318-321.18.S.Xue,L.FAN.ConstructionandsequencingofeukaryoticexpressionvectorofhumanLAIR-1-IgFcfusionproteingene.ImmunologicalJournal.2006,22(3):348-348.获得课题：1.国家自然科学基金面上项目（82171691），氧/ROS/DNA甲基化修饰调控轴对CryoClean新技术有效性和子代安全性的作用机制研究，2022-2025，主持。2.国家自然科学基金面上项目（31572546），布鲁氏菌LuxS/AI-2型密度感应系统的构建及其调控机制研究，2016-2019，合作单位主持。3.上海市市级医院新兴前沿技术联合攻关项目（SHDC12015122），无精子症生育力重建：精子获取与冻融前沿技术创立，2016-2018，合作单位主持。4.上海市自然科学基金项目（09ZR1417000），人微量精子冻存及升降温相关的损伤机理研究，2009-2011，主持。科研方向：卵子冷冻精子冷冻胚胎冷冻